Antiretroviral Protease Inhibitors Side Effects

An increase or decrease in body fat. Protease inhibitors can have side effects including.

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Newer HIV drugs including integrase inhibitors tend to cause fewer or milder side effects than older medications.

Antiretroviral protease inhibitors side effects. High blood sugar hyperglycemia and diabetes. Fatigue nausea headache and myalgia usually resolve 2-4 weeks after initiation. Metabolic side effects include glucose intolerance diabetes hypercholesterolemia and hypertriglyceridemia.

If this happens seek emergency medical care. Increased bilirubin is seen with atazanavir and indinavir. Nausea Vomiting Diarrhea Increased blood sugar levels.

Symptoms of liver damage may include jaundice which is a yellowing of the skin or whites of the eyes pale-colored stool or dark-colored urine. Myoblasts when cultured in media low in growth factors withdraw from the cell cycle express m. Although the toxic effects of HIV protease inhibitors could result from drug-drug interactions and overdose the off-target adverse drug effects of therapeutic doses is a major concern in drug design.

Side effects from long-term HAART therapy include loss of muscle mass. Increased cholesterol or triglyceride levels Rash Liver problems. Adverse effects associated with zidovudine include bone marrow.

May also occur with some of these agents. However the underlying molecular mechanisms responsible for highly active antiretroviral therapy HAART-induced cardio-metabolic effects are poorly understood. The antiretroviral protease inhibitors indinavir IDV and ritonavir RTV are used in highly active antiretroviral therapies HAART.

Side effects include. These side effects though uncommon require emergency medical care. In the HIV life cycle protease is an essential element for viral maturation.

Associated with neuropsychiatric symptoms rash liver toxicity and lipid abnormalities. Other adverse effects include psychiatric illness and insomnia. Other adverse effects are diarrhea nausea vomiting abdominal pain headache peripheral neuropathy abnormal sensations paresthesias reduced white blood counts increased liver enzymes and skin rash.

Common adverse events associated with protease inhibitors include gastrointestinal side effects diarrhea nausea vomiting and metabolic complications dyslipidemia insulin resistance. Nausea Vomiting Diarrhea Asthenia Hyperlipidemia Oral paresthesia abnormal tingling or burning sensation or numbness in the mouth Hyperglycemia. Other side effects include.

Antiretroviral drugs can cause side effects that can be severe enough to make some people stop taking them. They are generally well tolerated but are associated with weight gain. Adverse effects associated with the use of protease inhibitors nausea vomiting and diarrhea.

Although antiretroviral treatment decreases HIV-AIDS morbiditymortality long-term side effects may include the onset of insulin resistance and cardiovascular diseases. CCR5 Antagonist side effects Allergic reaction jaundice dark-colored urine vomiting abdominal pain fever fatigue myopathy mouth and skin blisters facial swelling trouble breathing upper respiratory tract infections cough joint pain myopathy pain below ribs heart problems and loss of appetite. The most commonly used NRTIs are zidovudine Retrovir lamivudine Epivir emtricitabine Emtriva and tenofovir Viread.

Headaches are a potential side effect of integrase inhibitors. Mild red itchy rash. Integrase Inhibitors side effects.

But if a person with HIV skips doses of these drugs the virus can start copying itself. Some side effects of protease inhibitors may be severe. And protease inhibitors are associated with gastrointestinal intolerance and glucose and lipid abnormalities.

Adjust dosage for renal insufficiency or failure. Higher risk of adverse effects than with some other NRTIs.

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